Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion
DISCOVERIES (ISSN 2359-7232),2014, July-September
CITATION:
Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion. Discoveries 2014, Jul-Sep; 2(3): e28. DOI: 10.15190/d.2014.20;
Submitted: September 4, 2014; Accepted: September 5, 2014; Published: September 8, 2014;
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Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion
Professor Bhanu P. Jena received his Ph.D. degree in Endocrinology, and the Research Excellence Award from Iowa State University in 1988. Following post-doctoral training at Iowa State and Yale Universities (1989-1994), Prof. Jena joined Yale University, as an Assistant Professor, and in 2000, moved to the Department of Physiology, at Wayne State University School of Medicine, as Professor, and Founder-Director of the Institute of NanoBioScience. In 2004, he was conferred the distinction of George E. Palade University Professor and Distinguished Professor. Prof. Jena is the only living University Professor, and the second in Wayne State University’s 160-year history. At a very early age, Prof. Jena was fascinated by the complexity of the cell, similar to the complexity of a city, yet every aspect of its operation precisely organized and coordinated. His scientific enquiry on how cells secrete which began more than 40 years ago, led to the discovery of the “porosome” -a new cellular structure and the universal secretory portal in cells.
Prof. Jena has received numerous awards and honors for his discoveries, among them: Elected Foreign Member of the Georgian National Academy of Science; Fellow AAAS; the Swebelius Cancer Research Award, the Hallim Distinguished Award Lecture jointly with Prof. Ahmed H. Zewail; Sir. Aaron Klug Award; ASAS Basic Biological Science Award; Ranbaxy Basic Research in Medical Sciences Award; Elected Foreign Member of the Korea Academy of Science & Technology; Elected Foreign Member of the National Academy of Medicine, Romania; George E. Palade Gold Medal, elected to the Academy of Scholars at Wayne State University; six Honorary Doctorates including one from Babes-Bolyai University, Romania, jointly with Professors George E. Palade and Günter Blobel, and Distinguished Visiting Professorships from a number of academic institutions.
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References
1. Schneider SW, Sritharan KC, Geibel JP, Oberleithner H, Jena BP. (1997) Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures involved in exocytosis. Proc Natl Acad Sci USA 94:316-321
2. Jena BP. (2007) Secretion machinery at the cell plasma membrane. Curr Opin Struct Biol 17:437-443
3. Jena BP. (2009) Porosome: the secretory portal in cells. Biochemistry 49:4009-4018
4. Jena BP. (2012) NanoCellBiology of Secretion: Imaging its Cellular and Molecular Underpinnings. Springer Briefs in Biological Imaging 1:1-70
5. Kovari LC, Brunzelle JS, Lewis KT, Cho W.J, Lee J-S, Taatjes DJ, Jena BP. (2014) X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron 56:37-43
6. Lee J-S, Jeremic A, Shin L, Cho WJ, Chen X, Jena BP. (2012) Neuronal Porosome proteome: Molecular dynamics and architecture. J Proteomics 75:3952-3962
7. Jena BP, Schneider SW, Geibel JP, Webster P, Oberleithner H, Sritharan KC. (1997) Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc Natl Acad Sci USA 94:13317-13322
8. Cho S-J, Sattar AKM, Jeong E-H, Satchi M, Cho J, Dash S, Mayes MS, Stromer MH, Jena BP. (2002) Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci USA 99:4720-4724
9. Kelly M, Cho W-J, Jeremic A, Abu-Hamdah R, Jena BP. (2004) Vesicle swelling regulates content expulsion during secretion. Cell Biol Int 28:709-716
10. Jena BP, Cho S-J, Jeremic A, Stromer MH, Abu-Hamdah R. (2003) Structure and composition of the fusion pore. Biophys J 84:1337-1343
11. Jeremic A, Kelly M, Cho S-J, Stromer MH, Jena BP. (2003) Reconstituted fusion pore. Biophys J 85:2035-2043
12. Cho S-J, Quinn AS, Stromer MH, Dash S, Cho J, Taatjes DJ, Jena BP. (2002) Structure and dynamics of the fusion pore in live cells. Cell Biol. Int 26:35-42
13. Almers W, Tse FW. (1990) Transmitter release from synapses: does a preassembled fusion pore initiate exocytosis? Neuron 4:813-818
14. Monck JR, Fernandez JM. (1992) The exocytotic fusion pore. J Cell Biol 119:1395-1404
15. Cho S-J, Wakade A, Pappas GD, Jena BP. (2002) New structure involved in transient membrane fusion and exocytosis. New York Academy of Science Annals 971:254-256
16. Cho S-J, Jeftinija K, Glavaski A, Jeftinija S, Jena BP, Anderson LL. (2002) Structure and dynamics of the fusion pores in live GH-secreting cells revealed using atomic force microscopy. Endocrinology 143:1144-1148
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