Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry
DISCOVERIES (ISSN 2359–7232), 2013, October-December
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Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry
Octavian Bucur (1)*, Alexandru Almasan (2), Barbara S. Nikolajczyk (3), Garth L. Nicolson (4), Jack Lawler (5), Victor E. Velculescu (6), Sorin Draghici (7), Mircea Leabu (8), Dorina Avram (9), Ilie Bucur (10), Enzo Calautti (11), George A. Calin (12), Subhash C. Chauhan (13), Mihai Ciubotaru (14), Stefan N. Constantinescu (15,16), Dipak Datta (17), Dan G. Duda (18), Mark T. Friedman (19), Paul J. Galardy (20), Brent T. Harris (21), Maite Huarte (22), Ahmad M. Khalil (23), Dario Marchetti (24), Liviu Movileanu (25), Roxana Nat (26), Carmelo Nucera (27), Aurel Popa-Wagner (28), Andreea L. Stancu (30), Shudong Zhu (29), Elisa A. Liehn (30)*
Affiliation:
(1) Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA; (2) Department of Cancer Biology, Lerner Research Institute & Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; (3) Boston University School of Medicine, Department of Microbiology, Boston, MA, USA; (4) The Institute for Molecular Medicine, Department of Molecular Pathology, Huntington Beach, CA, USA; (5) Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; (6) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287; (7) Intelligent Systems and Bioinformatics Laboratory, Wayne State University, Detroit, MI, USA; (8) Department of Cellular and Molecular Medicine, University of Medicine and Pharmacy “Carol Davila” and Victor Babes National Institute of Pathology, Bucharest, Romania; (9) Center for Cell Biology and Cancer Research & Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA; (10) Applied Systems, Craiova, Romania; (11) Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy; (12) Department of Experimental Therapeutics and Leukemia & Center for RNA Interference and Non-Coding RNAs, University of Texas MD Anderson Cancer Center, Houston, TX, USA; (13) Department of Pharmaceutical Sciences & Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee; (14) Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; (15) de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; (16) Ludwig Institute for Cancer Research, Brussels, Belgium; (17) CSIR-Central Drug Research Institute, Biochemistry Division, Lucknow, UP, India; (18) Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA; (19) Department of Pathology, St. Luke's-Roosevelt Hospital Center, Beth Israel Medical Center and Icahn School of Medicine at Mount Sinai, New York, NY, USA; (20) Department of Biochemistry and Molecular Biology & Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA; (21) Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC, USA; (22) Center for Applied Medical Research, University of Navarra, Pamplona, Spain; (23) Department of Genetics, Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; (24) Departments of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America; (25) Department of Physics, Structural Biology, Biochemistry, and Biophysics Program & Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA; (26) Institute for Neuroscience, Medical University Innsbruck, Innsbruck, Austria; (27) Human Thyroid Cancers Preclinical and Translational Research Laboratory, Experimental Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Simon C. Fireman Research Center and Harvard Medical School, Boston, MA, USA; (28) Department of Psychiatry, Rostock University Medical School, Rostock, Germany; (29) School of Biological Science and Technology, State Key Laboratory of Medical Genetics, Central South University, Changsha, China; (30) Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Germany.
*Corresponding authors:
Octavian Bucur, MD, Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. E-mail: obucur@bidmc.harvard.edu
Elisa A. Liehn, MD, PhD, Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. Phone: +49 241 8035983; Fax: +49 241 8082716; E-mail: eliehn@ukaachen.de
Access full text of the manuscript here: See full text (pdf) (updated 08/31/2018)*
* The initial article was updated on 08/31/2018 by including the first and last paragraphs of the main text as the Abstract. There are no other content changes performed (e.g no changes to the title, authors, affiliations, text content).
DISCOVERIES is a new peer-reviewed, open access, online multidisciplinary and integrative journal publishing high impact reviews, experimental articles, perspective articles, and editorials from all areas related to medicine, biology, and chemistry, including but not limited to: Molecular and Cellular Biology, Biochemistry, Biophysics, Genomics, Proteomics, Biotechnology, Synthetic Biology, Bioengineering, Systems Biology, Bioinformatics, Translational Medicine, Medicine/ Clinical findings, Cognitive Science, Epidemiology, Global Medicine, Family Medicine, Organic/ Inorganic/ Physical Chemistry and Ethics in Science.
DISCOVERIES brings to the research community an outstanding editorial board that aims to address several of the innovations proposed above: there is no need to format the manuscript before submission, we have a rapid and efficient submission process, there is no need for a Cover Letter and we support the need for rules for validation of critical reagents, such as antibodies. Discoveries will aim to support high quality research on human subjects materials to provide relevance for non-human studies along with mechanistic insights into human biology and chemistry. We also aim to avoid requesting unnecessary experiments during the review process, without affecting the quality and conclusions of published manuscripts. In addition, we recognize the need of adopting the recommendations made by NCCD and other similar scientific guiding entities.
References
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3. http://www.hsph.harvard.edu/biostats/lagakos/Lagakos_Curfman-Presentation.pdf
4. Bucur O, Pennarun B, Stancu AL, Nadler M, Muraru MS, Bertomeu T et al. Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP. Apoptosis 2013; 18(10):1154-62.
View article (DOI) PubMed5. Begley CG, Ellis LM. Drug development: raise standards for preclinical cancer research. Nature 2012; 483(7391): 531–533.
View article (DOI) PubMed6. Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov. 2011; 10(9): 712.
View article (DOI) PubMed7. Begley CG. Six red flags for suspect work. Nature 2013; 497(7450): 433-4.
View article (DOI) PubMed8. Mullard A. Reliability of ‘new drug target’ claims called into question. Nat Rev Drug Discov. 2011; 10(9): 643–644.
View article (DOI) PubMed9. http://blog.scienceexchange.com/2013/07/independant-antibody-validation-to-improve-research-quality/
10. http://www.aacrjournals.org/site/InstrAuthors/ifora.xhtml
11. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death, Cell Death Differ. 2009; 16(1): 3-11.
View article (DOI) PubMed12. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012; 19(1): 107-20.
View article (DOI) PubMed13. Bucur O, Stancu AL, Khosravi-Far R, Almasan A. Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications. Cell Death Dis. 2012; 3:e263.
View article (DOI) PubMed14. Ploegh H. End the wasteful tyranny of reviewer experiments. Nature 2011; 472(7344): 391.
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2022 Discoveries Award winning articles!
- Kinal Bhatt et al. 2021 (Larking Health System, FL, USA); Bhatt K, Agolli A, Patel MH, et al. High mortality co-infections of COVID-19 patients: mucormycosis and other fungal infections. Discoveries. 2021;9(1):e126.
27 citations in the past 1 year - $1000 prize- Hasnain Jan et al. 2020 (Quaid-i-Azam University, Pakistan); Jan H, Faisal S, Khan A, et al. COVID-19: Review of Epidemiology and Potential Treatments Against 2019 Novel Coronavirus. Discoveries. 2020;8(2):e108.
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2022 DISCOVERIES AWARDS! Discoveries will offer $1000 and $400 awards in early 2022, for the most cited (2021 ISI Citations) and visible (Altmetric Score) articles published in 2018-2021.
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After reaching all proposed milestones until now (including being indexed by Google Scholar in 2014), Discoveries' next Aim is PubMed indexing of all its articles (already published and upcoming). There will be no charge for the submission or publication of articles in Discoveries before PubMed indexing.
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We are happy to announce that our first Discoveries articles were included in PMC and PubMed. More articles (submitted by NIH funded articles) are now processed for being included.
Discoveries articles now on PubMed - April 2015 | Special Issue
DISCOVERIES publish the SPECIAL ISSUE entitled "INFLAMMATION BETWEEN DEFENSE AND DISEASE: Impact on Tissue Repair and Chronic Sickness".
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DISCOVERIES launched a call for papers for a Collection of Articles with focus on "ISCHEMIA". If you are interested to submit a manuscript, please contact us at info@discoveriesjournals.org
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DISCOVERIES launched a call for papers, for the SPECIAL ISSUE entitled "INFLAMMATION BETWEEN DEFENSE AND DISEASE: Impact on Tissue Repair and Chronic Sickness".
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DISCOVERIES just publish the SPECIAL ISSUE entitled "CELL SECRETION & MEMBRANE FUSION" in September 2014. Initially scheduled for publication between October 2014-March 2015, this issue was successfully published earlier than scheduled.
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All our published articles are now indexed by Google Scholar! Current citations for each individual article published in either Discoveries or Discoveries Reports are also shown. First citations to Discoveries articles are included! Search for the article's title or the authors:
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We are now ACCEPTING MANUSCRIPTS for publishing in DISCOVERIES. We aim to publish a small number of high impact experimental articles & reviews (around 40/year) to maintain a high impact factor. Domains of interest: all areas related to Medicine, Biology and Chemistry ...
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We are now ACCEPTING MANUSCRIPTS for DISCOVERIES REPORTS, publishing inovative and important research findings from all areas related to Medicine, Biology and Chemistry. We are also accepting experimental articles that validate/invalidate highly used reagents in current publications (ex. antibodies) and selected articles presenting negative data with impact and of wide scientific interest ...