DISCOVERIES REPORTS (ISSN 2393249X), 2020, volume 3

CITATION: 

Ayyazuddin A, Khan QU. An Interesting Case of Blood Group Switch after Breast Cancer Therapy. Discoveries Reports 2020; 3: e9. DOI: 10.15190/drep.2020.3

 Submitted: July 22, 2020; Revised: August 26, 2020; Accepted: August 29, 2020; Published: September 12, 2020;

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An Interesting Case of Blood Group Switch after Breast Cancer Therapy

Meher Ayyazuddin *, Qudsia Umaira Khan *

CMH Lahore Medical & Dental College Lahore, Lahore, Pakistan

*Correspondence to: Meher Ayyazuddin and Qudsia Umaira Khan, CMH Lahore Medical College and Institute of Dentistry, Abdur Rehman Road, Lahore Cantt, Pakistan; Emails: meherayyaz@hotmail.co.uk and drqudsia@yahoo.com respectively.

Abstract

Blood groups are determined by specific antigens attached to red blood cells that are either carbohydrate or protein in nature. Changes in gene expression encoding for various blood types are rare, with the ABO blood group antigen most commonly altered. We report a female patient whose blood group changed from A, Rh positive to A, Rh negative, over the period of 10 years (1999-2009). During this time period, she was diagnosed with breast carcinoma and a lumpectomy was performed, followed by chemotherapy (with anthracycline and docetaxel) along with local irradiation. There has been no remission after recovery. It was noticed that the patient’s blood group had changed. A possible reason may be Rh mosaicism and a mutation in the Rh gene, resulting in the alteration of Rh antigen expression. The reason causing this mutation is unclear. However, in some cases changes in blood groups are related to patients’ chemotherapy treatment and their remission status.

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