DISCOVERIES (ISSN 2359-7232), 2015, January-March issue
Uzoni A, Ciobanu O, Sandu RE, Buga AM, Popa-Wagner A. Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects. Discoveries 2015, Jan-Mar; 3(1): e39. DOI: 10.15190/d.2015.31
Submitted: March 09, 2015; Revised: March 27, 2015; Accepted: March 27, 2015; Published: March 31, 2015;
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Life style, Perfusion deficits and Co-morbidities Precipitate Inflammation and Cerebrovascular Disorders in Aged Subjects
Adriana Uzoni (1,4), Ovidiu Ciobanu (2,3), Raluca Elena Sandu (2), Ana Maria Buga (1,2), Aurel Popa-Wagner (1,2,*)
(1) Department of Psychiatry, University of Medicine Rostock, Germany
(2) Center of Clinical and Experimental Research, University of Medicine and Pharmacy, Craiova, Romania
(3) Department of Psychiatry, University Medicine of Saarland, Homburg/Saar, Germany
(4) Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
*Correspondence to: Aurel Popa-Wagner, MD, PhD, Department of Psychiatry, University of Medicine Rostock, Gehlsheimerstr. 20, 18147 Rostock, Germany. Phone: +49-381-494-9686; Fax: +49-381-494-9639; E-mail: aurel.popa-wagner@med.uni-rostock.de
Abstract
Cerebrovascular diseases represent 2nd leading cause of death worldwide. Understanding how genetic predispositions and their interaction with environmental factors affect cerebrovascular diseases is fundamental for prevention, diagnosis and for the development of safe and efficient therapies. Cerebrovascular diseases have not only a very high mortality rate, but also results in debilitating neurological impairments or permanent disability in survivors associated with huge economic losses. Among the women and men individuals with a low-risk lifestyle (smoking, exercising daily, consuming a prudent diet including moderate alcohol and having a healthy weight during mid-life) had a significantly lower risk of stroke than individuals without a low-risk lifestyle. Current review focuses on determining the relationship between diet, as an important component of ‘life style’, aging and cerebrovascular diseases.This review may help to unravel biological mechanisms linking lifestyle, diet-induced, metabolic inflammation, aging and cerebral hypoperfusion to development of cerebrovascular diseases, a prerequisite for development of science-based preventive strategies needed to combat the major public health challenges like obesity and stroke
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